Research Teams' Projects

IDIBELL Research Team projects

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Projects

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34 projects

Ability of a polygenic risk score to refine cancer risk in Lynch syndrome

Assessment of a novel pan-cancer biomarker to improve immunotherapy response prediction

Autoantibodies against type I interferons continue to confer a higher risk of severe COVID-19 in fully vaccinated population

Understanding the risk factors behind the most severe cases of COVID-19

Understanding the risk factors behind the most severe cases of COVID-19Translational Medicine Area

Building the Network of Rare Ovarian Tumors (NRTO), an intercontinental initiative

Ovarian cancer susceptibility syndromes

Ovarian cancer susceptibility syndromesTranslational Medicine Area

Characterization of the novel DGCR8-microprocessor syndrome

miRNA biogenesis associated tumors 

miRNA biogenesis associated tumors Translational Medicine Area

Characterizing early events driving carcinogenesis in Constitutional Mismatch Repair Deficiency (CMMRD) syndrome as a potential strategy for precision surveillance and prevention

Clarifying the phenotypic spectrum associated with RAD51 partners and the proteomic interplay of RAD51 paralogs.

Novel DNA repair associated tumor syndromes

Novel DNA repair associated tumor syndromesTranslational Medicine Area

Clinical and molecular characterization of novel subtypes of Sex Cord-Stromal Tumors of the ovary

Ovarian cancer susceptibility syndromes

Ovarian cancer susceptibility syndromesTranslational Medicine Area

Comprehensive research in colorectal cancer and polyposis predisposition: searching for genetic and epigenetic causes of the disease

Identification of new genes involved in the predisposition of colorectal cancer and polyposis

Identification of new genes involved in the predisposition of colorectal cancer and polyposisTranslational Medicine Area

CRISPR/Cas9-edited organoids for the functional evaluation of gene variants in colorectal cancer

Establishment, optimization and implementation of state-of-the-art models for the functional characterization of genetic variants in hereditary cancer genes

Establishment, optimization and implementation of state-of-the-art models for the functional characterization of genetic variants in hereditary cancer genesTranslational Medicine Area

Elucidating the molecular mechanisms driven by FGFR1 mutants in Low Grade Gliomas

Oncogenic mutations and pediatric cancer syndromes. 

Oncogenic mutations and pediatric cancer syndromes. Translational Medicine Area

Hereditary Cancer Research Group – AGAUR

Participation in national and regional initiatives of genomic-based precision medicine in cancer

Participation in national and regional initiatives of genomic-based precision medicine in cancerTranslational Medicine Area

Hereditary forms and development of biomarkers in gastrointestinal cancer

IMPaCT Genómica: Implementation of Precision Medicine in the Spanish National Health System.

Participation in national and regional initiatives of genomic-based precision medicine in cancer

Participation in national and regional initiatives of genomic-based precision medicine in cancerTranslational Medicine Area

IMPaCT-VUScan: Development and implementation of a functional genomics platform for undiagnosed hereditary cancer

Participation in national and regional initiatives of genomic-based precision medicine in cancer

Participation in national and regional initiatives of genomic-based precision medicine in cancerTranslational Medicine Area

INGENIO: Integrative genomic, digital imaging and clinical information towards precision oncology optimization

Participation in the development of international guidelines for hereditary or early-onset colorectal cancer

Participation in the development of international guidelines for hereditary or early-onset colorectal cancerTranslational Medicine Area

MedPerCan: Personalised Medicine in Cancer – Catalonia: A pilot study on the impact of genomic testing in the decision-making process in Oncology

Participation in the development of international guidelines for hereditary or early-onset colorectal cancer

Participation in the development of international guidelines for hereditary or early-onset colorectal cancerTranslational Medicine Area

MicroRNAs in sporadic and familial colorectal cancer

Identification of new genes involved in the predisposition of colorectal cancer and polyposis

Identification of new genes involved in the predisposition of colorectal cancer and polyposisTranslational Medicine Area

Modeling precancer in germline mismatch repair deficiency for a personalized immune-based surveillance (MIsMatch4PERSON)

National collaborative strategy to improve the identification and clinical management of Constitutional Mismatch Repair Deficiency (CMMRD) syndrome

Neutralizing autoantibodies against type I interferons continue to confer a higher risk of severe COVID-19 in fully vaccinated population

Understanding the risk factors behind the most severe cases of COVID-19

Understanding the risk factors behind the most severe cases of COVID-19Translational Medicine Area

NF1 nonsense suppression by targeted pseudouridylation

Identification of new personalized therapeutic agents against Malignant peripheral nerve sheath tumors (MPNSTs)

Identification of new personalized therapeutic agents against Malignant peripheral nerve sheath tumors (MPNSTs)Translational Medicine Area

Non-conventional mechanisms of gene inactivation in hereditary colorectal cancer

Pancreatic orthotopic PDX mouse models as tools to test new therapeutic strategies for pancreatic cancer

ProofREAD4MED: Polymerase proofreading-deficient tumors: genetics and immune biology insights for improved predictive medicine

Clinical and molecular characterization of hereditary cancer syndromes and genes, with special focus on polyposis syndromes

Clinical and molecular characterization of hereditary cancer syndromes and genes, with special focus on polyposis syndromesTranslational Medicine Area

Role of immune system inborn errors as determinants of the COVID-19 severity in hospitalized patients

Understanding the risk factors behind the most severe cases of COVID-19

Understanding the risk factors behind the most severe cases of COVID-19Translational Medicine Area

SOLVE-RD: Solving the unsolved rare diseases

Identification of new genes involved in the predisposition of colorectal cancer and polyposis

Identification of new genes involved in the predisposition of colorectal cancer and polyposisTranslational Medicine Area

SpadaHC: Spanish DataBase for Hereditary Cancer

Participation in the development of international guidelines for hereditary or early-onset colorectal cancer

Participation in the development of international guidelines for hereditary or early-onset colorectal cancerTranslational Medicine Area

Tackling current challenges in the genetic diagnosis of hereditary cancer through integrative analysis of molecular, clinical and population data

Improving clinical applicability of multi-gene panels in the setting of hereditary cancer

Improving clinical applicability of multi-gene panels in the setting of hereditary cancerTranslational Medicine Area

Testing the Malignant Peripheral Nerve Sheath Tumor vulnerability to precision therapies directed to recurrent genomic alterations

Identification of new personalized therapeutic agents against Malignant peripheral nerve sheath tumors (MPNSTs)

Identification of new personalized therapeutic agents against Malignant peripheral nerve sheath tumors (MPNSTs)Translational Medicine Area

The mechanistic basis for constitutional MLH1 methylation

To uncover the genetic causes of Gorlin-like patients without an identified molecular cause.

Oncogenic mutations and pediatric cancer syndromes. 

Oncogenic mutations and pediatric cancer syndromes. Translational Medicine Area

Underpining the effects of defective miRNA biogenesis in the formation of thyroid tumors

miRNA biogenesis associated tumors 

miRNA biogenesis associated tumors Translational Medicine Area

Validation of the clinical use of high-sensitivity microsatellite instability assessment in improving early diagnosis of endometrial cancer and establishing personalized gynecological follow-up strategies in Lynch syndrome

proyectos