Ability of a polygenic risk score to refine cancer risk in Lynch syndrome

ABOUT THE PROJECT

Lynch syndrome is characterized by incomplete penetrance. One of the main current challenges is to identify risk-modifying factors which modulate the expressivity of the disease. Genetic risk modifiers (i.e. Polygenic risk score, PRS) have been described to model the colorectal cancer (CRC) risk in general population, but their effect on CRC risk in Lynch syndrome individuals is controversial. Our objective is to evaluate whether differences in CRC penetrance in European descendant LS individuals can be in part explained by the accumulation of CRC low-risk alleles.