ABOUT THE PROJECT
Dysembryoplastic neuroepithelial tumors (DNETs) are low grade brain tumors due to oncogenic alterations in the FGFR1 gene. We showed that inherited mutations in FGFR1 are responsible for familial form of this disease. Thorough characterization of these tumors allowed us to identify a high prevalence of multiple mutants in cis as a feature of DNETs, suggesting the need of a specific level of signaling as a mechanism to confer susceptibility and drive low grade tumors, thus potentially opening a new avenue for targeted therapies of these epileptogenic tumors.
Funding
Alex's Lemonade Stand Foundation
Fundació La Caixa
Mia Neri Foundation
Burroughs Wellcome Fund
Contact
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