National collaborative strategy to improve the identification and clinical management of Constitutional Mismatch Repair Deficiency (CMMRD) syndrome
DNA MisMatch Repair Lab
Validation of the clinical use of high-sensitivity microsatellite instability assessment in improving early diagnosis of endometrial cancer and establishing personalized gynecological follow-up strategies in Lynch syndrome
DNA MisMatch Repair Lab
Underpining the effects of defective miRNA biogenesis in the formation of thyroid tumors
Assessment of a novel pan-cancer biomarker to improve immunotherapy response prediction
DNA MisMatch Repair Lab
Characterizing early events driving carcinogenesis in Constitutional Mismatch Repair Deficiency (CMMRD) syndrome as a potential strategy for precision surveillance and prevention
DNA MisMatch Repair Lab
Modeling precancer in germline mismatch repair deficiency for a personalized immune-based surveillance (MIsMatch4PERSON)
DNA MisMatch Repair Lab
The mechanistic basis for constitutional MLH1 methylation
DNA MisMatch Repair Lab
Neutralizing autoantibodies against type I interferons continue to confer a higher risk of severe COVID-19 in fully vaccinated population
Genetic Susceptibility to Severe Covid-19 Team
Autoantibodies against type I interferons continue to confer a higher risk of severe COVID-19 in fully vaccinated population
Genetic Susceptibility to Severe Covid-19 Team
Role of immune system inborn errors as determinants of the COVID-19 severity in hospitalized patients
Genetic Susceptibility to Severe Covid-19 Team
Tackling current challenges in the genetic diagnosis of hereditary cancer through integrative analysis of molecular, clinical and population data
Improving Genetic Diagnostics Team
NF1 nonsense suppression by targeted pseudouridylation
Neurofibromatosis team
Testing the Malignant Peripheral Nerve Sheath Tumor vulnerability to precision therapies directed to recurrent genomic alterations
Neurofibromatosis team
Clarifying the phenotypic spectrum associated with RAD51 partners and the proteomic interplay of RAD51 paralogs.
Rare TumorS Lab
Building the Network of Rare Ovarian Tumors (NRTO), an intercontinental initiative
Rare TumorS Lab
Clinical and molecular characterization of novel subtypes of Sex Cord-Stromal Tumors of the ovary
Rare TumorS Lab
To uncover the genetic causes of Gorlin-like patients without an identified molecular cause.
Rare TumorS Lab
Elucidating the molecular mechanisms driven by FGFR1 mutants in Low Grade Gliomas
Rare TumorS Lab
Characterization of the novel DGCR8-microprocessor syndrome
Rare TumorS Lab
CRISPR/Cas9-edited organoids for the functional evaluation of gene variants in colorectal cancer
ProofREAD4MED: Polymerase proofreading-deficient tumors: genetics and immune biology insights for improved predictive medicine
Colorectal Cancer Predisposition
Non-conventional mechanisms of gene inactivation in hereditary colorectal cancer
Comprehensive research in colorectal cancer and polyposis predisposition: searching for genetic and epigenetic causes of the disease
MicroRNAs in sporadic and familial colorectal cancer
SOLVE-RD: Solving the unsolved rare diseases
Colorectal Cancer Predisposition Lab